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The timing of TCRα expression critically influences T cell development and selection
Sequential rearrangement of the T cell receptor for antigen (TCR) β and α chains is a hallmark of thymocyte development. This temporal control is lost in TCR transgenics because the α chain is expressed prematurely at the CD4(−)CD8(−) double negative (DN) stage. To test the importance of this, we ex...
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| Autori principali: | , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
The Rockefeller University Press
2005
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2212895/ https://ncbi.nlm.nih.gov/pubmed/15998791 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20050359 |
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