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Contrasting models of promiscuous gene expression by thymic epithelium
Medullary thymic epithelial cells (mTECs) express a broad spectrum of tissue- restricted self-antigens (TRAs), which are required for the development of central tolerance. A new study suggests that TRA expression is a specialized property of terminally differentiated mTECs. However, as discussed her...
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| Main Authors: | , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
The Rockefeller University Press
2005
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2212887/ https://ncbi.nlm.nih.gov/pubmed/15983067 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20050976 |
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