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Contrasting models of promiscuous gene expression by thymic epithelium

Medullary thymic epithelial cells (mTECs) express a broad spectrum of tissue- restricted self-antigens (TRAs), which are required for the development of central tolerance. A new study suggests that TRA expression is a specialized property of terminally differentiated mTECs. However, as discussed her...

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Библиографические подробности
Главные авторы: Gillard, Geoffrey O., Farr, Andrew G.
Формат: Artigo
Язык:Inglês
Опубликовано: The Rockefeller University Press 2005
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2212887/
https://ncbi.nlm.nih.gov/pubmed/15983067
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20050976
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