Coexistence of multivalent and monovalent TCRs explains high sensitivity and wide range of response

A long-standing paradox in the study of T cell antigen recognition is that of the high specificity–low affinity T cell receptor (TCR)–major histocompatibility complex peptide (MHCp) interaction. The existence of multivalent TCRs could resolve this paradox because they can simultaneously improve the...

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Détails bibliographiques
Auteurs principaux: Schamel, Wolfgang W.A., Arechaga, Ignacio, Risueño, Ruth M., van Santen, Hisse M., Cabezas, Pilar, Risco, Cristina, Valpuesta, José M., Alarcón, Balbino
Format: Artigo
Langue:Inglês
Publié: The Rockefeller University Press 2005
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2212847/
https://ncbi.nlm.nih.gov/pubmed/16087711
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20042155
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