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A conformational change senses the strength of T cell receptor–ligand interaction during thymic selection

T cell antigen receptor (TCR) triggering determines the fate of immature thymocytes. The affinity of the TCR for its endogenous peptide/MHC ligands serves as a signal for positive or negative selection through mechanisms that are still little understood. We have used a conformation-specific antibody...

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Bibliografiske detaljer
Main Authors: Risueño, Ruth M., van Santen, Hisse M., Alarcón, Balbino
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2006
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1480457/
https://ncbi.nlm.nih.gov/pubmed/16766661
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0601785103
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