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T Cell Receptor Engagement Triggers Its CD3ε and CD3ζ Subunits to Adopt a Compact, Locked Conformation

How the T cell antigen receptor (TCR) discriminates between molecularly related peptide/Major Histocompatibility Complex (pMHC) ligands and converts this information into different possible signaling outcomes is still not understood. One current model proposes that strong pMHC ligands, but not weak...

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Detalhes bibliográficos
Main Authors: Risueño, Ruth M., Schamel, Wolfgang W. A., Alarcón, Balbino
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2254190/
https://ncbi.nlm.nih.gov/pubmed/18320063
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0001747
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