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Models of Self-Peptide Sampling by Developing T Cells Identify Candidate Mechanisms of Thymic Selection
Conventional and regulatory T cells develop in the thymus where they are exposed to samples of self-peptide MHC (pMHC) ligands. This probabilistic process selects for cells within a range of responsiveness that allows the detection of foreign antigen without excessive responses to self. Regulatory T...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3723501/ https://ncbi.nlm.nih.gov/pubmed/23935465 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1003102 |
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