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NFATc2 and NFATc3 transcription factors play a crucial role in suppression of CD4(+) T lymphocytes by CD4(+) CD25(+) regulatory T cells
The phenotype of NFATc2(−/−) c3(−/−) (double knockout [DKO]) mice implies a disturbed regulation of T cell responses, evidenced by massive lymphadenopathy, splenomegaly, and autoaggressive phenomena. The population of CD4(+) CD25(+) T cells from DKO mice lacks regulatory capacity, except a small sub...
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| Autori principali: | , , , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
The Rockefeller University Press
2005
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2212786/ https://ncbi.nlm.nih.gov/pubmed/15657288 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20041538 |
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