NFATc2 and NFATc3 transcription factors play a crucial role in suppression of CD4(+) T lymphocytes by CD4(+) CD25(+) regulatory T cells

The phenotype of NFATc2(−/−) c3(−/−) (double knockout [DKO]) mice implies a disturbed regulation of T cell responses, evidenced by massive lymphadenopathy, splenomegaly, and autoaggressive phenomena. The population of CD4(+) CD25(+) T cells from DKO mice lacks regulatory capacity, except a small sub...

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Bibliographische Detailangaben
Hauptverfasser: Bopp, Tobias, Palmetshofer, Alois, Serfling, Edgar, Heib, Valeska, Schmitt, Steffen, Richter, Christoph, Klein, Matthias, Schild, Hansjörg, Schmitt, Edgar, Stassen, Michael
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Rockefeller University Press 2005
Schlagworte:
Brief Definitive Report
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2212786/
https://ncbi.nlm.nih.gov/pubmed/15657288
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20041538
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