Infectious Tolerance: Human CD25(+) Regulatory T Cells Convey Suppressor Activity to Conventional CD4(+) T Helper Cells

Regulatory CD4(+)CD25(+) T cells (Treg) are mandatory for maintaining immunologic self-tolerance. We demonstrate that the cell-cell contact–mediated suppression of conventional CD4(+) T cells by human CD25(+) Treg cells is fixation resistant, independent from membrane-bound TGF-β but requires activa...

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Autores principales: Jonuleit, Helmut, Schmitt, Edgar, Kakirman, Hacer, Stassen, Michael, Knop, Jürgen, Enk, Alexander H.
Formato: Artigo
Lenguaje:Inglês
Publicado: The Rockefeller University Press 2002
Materias:
Brief Definitive Report
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2193929/
https://ncbi.nlm.nih.gov/pubmed/12119350
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20020394
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