Cyclic AMP-induced Chromatin Changes Support the NFATc-mediated Recruitment of GATA-3 to the Interleukin 5 Promoter

Elevated intracellular cyclic AMP levels, which suppress the proliferation of naive T cells and type 1 T helper (Th1) cells are a property of T helper 2 (Th2) cells and regulatory T cells. While cyclic AMP signals interfere with the IL-2 promoter induction, they support the induction of Th2-type gen...

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Detalhes bibliográficos
Main Authors: Klein-Hessling, Stefan, Bopp, Tobias, Jha, Mithilesh K., Schmidt, Arthur, Miyatake, Shoichiro, Schmitt, Edgar, Serfling, Edgar
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2008
Assuntos:
Transcription, Chromatin, and Epigenetics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2662173/
https://ncbi.nlm.nih.gov/pubmed/18772129
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M805929200
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