Gene array identification of Ipf1/Pdx1(-/- )regulated genes in pancreatic progenitor cells

BACKGROUND: The homeodomain transcription factor IPF1/PDX1 exerts a dual role in the pancreas; Ipf1/Pdx1 global null mutants fail to develop a pancreas whereas conditional inactivation of Ipf1/Pdx1 in β-cells leads to impaired β-cell function and diabetes. Although several putative target genes have...

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Bibliographic Details
Main Authors: Svensson, Per, Williams, Cecilia, Lundeberg, Joakim, Rydén, Patrik, Bergqvist, Ingela, Edlund, Helena
Format: Artigo
Language:Inglês
Published: BioMed Central 2007
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2212654/
https://ncbi.nlm.nih.gov/pubmed/18036209
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-213X-7-129
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