The Sequence Alteration Associated with a Mutational Hotspot in p53 Protects Cells From Lysis by Cytotoxic T Lymphocytes Specific for a Flanking Peptide Epitope

A high proportion of tumors arise due to mutation of the p53 tumor suppressor protein. A p53 hotspot mutation at amino acid position 273 from R to H, flanking a peptide epitope that spans residues 264–272, renders cells resistant to killing by human histocompatibility leukocyte antigen (HLA)-A*0201–...

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Главные авторы: Theobald, Matthias, Ruppert, Thomas, Kuckelkorn, Ulrike, Hernandez, Javier, Häussler, Annett, Ferreira, Edite Antunes, Liewer, Ulrike, Biggs, Judith, Levine, Arnold J., Huber, Christoph, Koszinowski, Ulrich H., Kloetzel, Peter-M., Sherman, Linda A.
Формат: Artigo
Язык:Inglês
Опубликовано: The Rockefeller University Press 1998
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Articles
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2212538/
https://ncbi.nlm.nih.gov/pubmed/9743520
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