The Sequence Alteration Associated with a Mutational Hotspot in p53 Protects Cells From Lysis by Cytotoxic T Lymphocytes Specific for a Flanking Peptide Epitope

A high proportion of tumors arise due to mutation of the p53 tumor suppressor protein. A p53 hotspot mutation at amino acid position 273 from R to H, flanking a peptide epitope that spans residues 264–272, renders cells resistant to killing by human histocompatibility leukocyte antigen (HLA)-A*0201–...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Theobald, Matthias, Ruppert, Thomas, Kuckelkorn, Ulrike, Hernandez, Javier, Häussler, Annett, Ferreira, Edite Antunes, Liewer, Ulrike, Biggs, Judith, Levine, Arnold J., Huber, Christoph, Koszinowski, Ulrich H., Kloetzel, Peter-M., Sherman, Linda A.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 1998
Assuntos:
Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2212538/
https://ncbi.nlm.nih.gov/pubmed/9743520
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados