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A Role for Fas in Negative Selection of Thymocytes In Vivo

To seek information on the role of Fas in negative selection, we examined subsets of thymocytes from normal neonatal mice versus Fas-deficient lpr/lpr mice injected with graded doses of antigen. In normal mice, injection of 1–100 μg of staphylococcal enterotoxin B (SEB) induced clonal elimination of...

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Autori principali: Kishimoto, Hidehiro, Surh, Charles D., Sprent, Jonathan
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Rockefeller University Press 1998
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2212270/
https://ncbi.nlm.nih.gov/pubmed/9565635
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