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Yeast as a model of human mitochondrial tRNA base substitutions: Investigation of the molecular basis of respiratory defects

We investigate the relationships between acylation defects and structure alterations due to base substitutions in yeast mitochondrial (mt) tRNA(UUR) (Leu). The studied substitutions are equivalent to the A3243G and T3250C human pathogenetic tRNA mutations. Our data show that both mutations can produ...

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Detalhes bibliográficos
Main Authors: Montanari, Arianna, Besagni, Céline, De Luca, Cristina, Morea, Veronica, Oliva, Romina, Tramontano, Anna, Bolotin-Fukuhara, Monique, Frontali, Laura, Francisci, Silvia
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2008
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2212258/
https://ncbi.nlm.nih.gov/pubmed/18065717
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.740108
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