The yeast counterparts of human 'MELAS' mutations cause mitochondrial dysfunction that can be rescued by overexpression of the mitochondrial translation factor EF-Tu

We have taken advantage of the similarity between human and yeast (Saccharomyces cerevisiae) mitochondrial tRNA(Leu)(UUR), and of the possibility of transforming yeast mitochondria, to construct yeast mitochondrial mutations in the gene encoding tRNA(Leu)(UUR) equivalent to the human A3243G, C3256T...

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Détails bibliographiques
Auteurs principaux: Feuermann, M., Francisci, S., Rinaldi, T., De Luca, C., Rohou, H., Frontali, L., Bolotin-Fukuhara, M.
Format: Artigo
Langue:Inglês
Publié: 2003
Sujets:
Scientific Report
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC1315813/
https://ncbi.nlm.nih.gov/pubmed/12524521
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.embor.embor713
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