The yeast counterparts of human 'MELAS' mutations cause mitochondrial dysfunction that can be rescued by overexpression of the mitochondrial translation factor EF-Tu

We have taken advantage of the similarity between human and yeast (Saccharomyces cerevisiae) mitochondrial tRNA(Leu)(UUR), and of the possibility of transforming yeast mitochondria, to construct yeast mitochondrial mutations in the gene encoding tRNA(Leu)(UUR) equivalent to the human A3243G, C3256T...

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Detalhes bibliográficos
Main Authors: Feuermann, M., Francisci, S., Rinaldi, T., De Luca, C., Rohou, H., Frontali, L., Bolotin-Fukuhara, M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2003
Assuntos:
Scientific Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1315813/
https://ncbi.nlm.nih.gov/pubmed/12524521
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.embor.embor713
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