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The bacterial toxin RelE induces specific mRNA cleavage in the A site of the eukaryote ribosome

RelE/RelB is a well-characterized toxin–anti-toxin pair involved in nutritional stress responses in Bacteria and Archae. RelE lacks any eukaryote homolog, but we demonstrate here that it efficiently and specifically cleaves mRNA in the A site of the eukaryote ribosome. The cleavage mechanism is simi...

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Hlavní autoři: Andreev, Dmitri, Hauryliuk, Vasili, Terenin, Ilya, Dmitriev, Sergey, Ehrenberg, Måns, Shatsky, Ivan
Médium: Artigo
Jazyk:Inglês
Vydáno: Cold Spring Harbor Laboratory Press 2008
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2212246/
https://ncbi.nlm.nih.gov/pubmed/18083838
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.693208
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