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GTP-independent tRNA Delivery to the Ribosomal P-site by a Novel Eukaryotic Translation Factor

During translation, aminoacyl-tRNAs are delivered to the ribosome by specialized GTPases called translation factors. Here, we report the tRNA binding to the P-site of 40 S ribosomes by a novel GTP-independent factor eIF2D isolated from mammalian cells. The binding of tRNA(i)(Met) occurs after the AU...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Dmitriev, Sergey E., Terenin, Ilya M., Andreev, Dmitri E., Ivanov, Pavel A., Dunaevsky, Jacov E., Merrick, William C., Shatsky, Ivan N.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2010
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2930676/
https://ncbi.nlm.nih.gov/pubmed/20566627
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.119693
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