A Leaderless mRNA Can Bind to Mammalian 80S Ribosomes and Direct Polypeptide Synthesis in the Absence of Translation Initiation Factors

Translation initiation in eukaryotic cells is known to be a complex multistep process which involves numerous protein factors. Here we demonstrate that leaderless mRNAs with initiator Met-tRNA can bind directly to 80S mammalian ribosomes in the absence of initiation factors and that the complexes th...

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Bibliografiska uppgifter
Huvudupphovsmän: Andreev, Dmitri E., Terenin, Ilya M., Dunaevsky, Yan E., Dmitriev, Sergei E., Shatsky, Ivan N.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Microbiology 2006
Ämnen:
Articles
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC1446950/
https://ncbi.nlm.nih.gov/pubmed/16581790
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.26.8.3164-3169.2006
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