Differential contribution of the m(7)G-cap to the 5′ end-dependent translation initiation of mammalian mRNAs

Many mammalian mRNAs possess long 5′ UTRs with numerous stem-loop structures. For some of them, the presence of Internal Ribosome Entry Sites (IRESes) was suggested to explain their significant activity, especially when cap-dependent translation is compromised. To test this hypothesis, we have compa...

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Hlavní autoři: Andreev, Dmitri E., Dmitriev, Sergey E., Terenin, Ilya M., Prassolov, Vladimir S., Merrick, William C., Shatsky, Ivan N.
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2009
Témata:
Molecular Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2764426/
https://ncbi.nlm.nih.gov/pubmed/19696074
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkp665
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