Efficient Translation Initiation Directed by the 900-Nucleotide-Long and GC-Rich 5′ Untranslated Region of the Human Retrotransposon LINE-1 mRNA Is Strictly Cap Dependent Rather than Internal Ribosome Entry Site Mediated

Retrotransposon L1 is a mobile genetic element of the LINE family that is extremely widespread in the mammalian genome. It encodes a dicistronic mRNA, which is exceptionally rare among eukaryotic cellular mRNAs. The extremely long and GC-rich L1 5′ untranslated region (5′UTR) directs synthesis of nu...

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Main Authors: Dmitriev, Sergey E., Andreev, Dmitri E., Terenin, Ilya M., Olovnikov, Ivan A., Prassolov, Vladimir S., Merrick, William C., Shatsky, Ivan N.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2007
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1951496/
https://ncbi.nlm.nih.gov/pubmed/17470553
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.02138-06
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