Enhanced TCR-induced Apoptosis in Interferon Regulatory Factor 4–deficient CD4(+) Th Cells

Transcription factors of the interferon regulatory factor (IRF) family contribute to the regulation of cell proliferation and apoptosis. Here, we show that CD4(+) T helper (Th) cells lacking IRF4 (IRF4(−/−)) are highly sensitive to apoptosis. After infection of IRF4(−/−) mice with the protozoan para...

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Detalhes bibliográficos
Main Authors: Lohoff, Michael, Mittrücker, Hans-Willi, Brüstle, Anne, Sommer, Frank, Casper, Bärbel, Huber, Magda, Ferrick, David A., Duncan, Gordon S., Mak, Tak W.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2004
Assuntos:
Brief Definitive Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2212018/
https://ncbi.nlm.nih.gov/pubmed/15249594
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20040182
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