GITR Activation Induces an Opposite Effect on Alloreactive CD4(+) and CD8(+) T Cells in Graft-Versus-Host Disease

Glucocorticoid-induced tumor necrosis factor receptor family-related gene (GITR) is a member of the tumor necrosis factor receptor (TNFR) family that is expressed at low levels on unstimulated T cells, B cells, and macrophages. Upon activation, CD4(+) and CD8(+) T cells up-regulate GITR expression,...

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Autors principals: Muriglan, Stephanie J., Ramirez-Montagut, Teresa, Alpdogan, Onder, van Huystee, Thomas W., Eng, Jeffrey M., Hubbard, Vanessa M., Kochman, Adam A., Tjoe, Kartono H., Riccardi, Carlo, Pandolfi, Pier Paolo, Sakaguchi, Shimon, Houghton, Alan N., van den Brink, Marcel R.M.
Format: Artigo
Idioma:Inglês
Publicat: The Rockefeller University Press 2004
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2212013/
https://ncbi.nlm.nih.gov/pubmed/15249593
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20040116
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