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Tumor Necrosis Factor (TNF) Receptor Shedding Controls Thresholds of Innate Immune Activation That Balance Opposing TNF Functions in Infectious and Inflammatory Diseases

Tumor necrosis factor (TNF) is a potent cytokine exerting critical functions in the activation and regulation of immune and inflammatory responses. Due to its pleiotropic activities, the amplitude and duration of TNF function must be tightly regulated. One of the mechanisms that may have evolved to...

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Autori principali: Xanthoulea, Sofia, Pasparakis, Manolis, Kousteni, Stavroula, Brakebusch, Cord, Wallach, David, Bauer, Jan, Lassmann, Hans, Kollias, George
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Rockefeller University Press 2004
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2211976/
https://ncbi.nlm.nih.gov/pubmed/15289505
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20040435
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