Tumor Necrosis Factor (TNF) Receptor Shedding Controls Thresholds of Innate Immune Activation That Balance Opposing TNF Functions in Infectious and Inflammatory Diseases

Tumor necrosis factor (TNF) is a potent cytokine exerting critical functions in the activation and regulation of immune and inflammatory responses. Due to its pleiotropic activities, the amplitude and duration of TNF function must be tightly regulated. One of the mechanisms that may have evolved to...

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Main Authors: Xanthoulea, Sofia, Pasparakis, Manolis, Kousteni, Stavroula, Brakebusch, Cord, Wallach, David, Bauer, Jan, Lassmann, Hans, Kollias, George
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2004
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2211976/
https://ncbi.nlm.nih.gov/pubmed/15289505
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20040435
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