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Distinct binding modes specify the recognition of methylated histones H3K4 and H4K20 by JMJD2A-tudor
The lysine demethylase JMJD2A has the unique property of binding trimethylated peptides from two different histone sequences (H3K4me3 and H4K20me3) through its tudor domains. Here we show using X-ray crystallography and calorimetry that H3K4me3 and H4K20me3, which are recognized with similar affinit...
Tallennettuna:
| Päätekijät: | , , , |
|---|---|
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
2007
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2211384/ https://ncbi.nlm.nih.gov/pubmed/18084306 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb1326 |
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