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Destabilization of human glycine N-methyltransferase by H176N mutation
In the presence of moderate (2–4 M) urea concentrations the tetrameric enzyme, glycine N-methyltransferase (GNMT), dissociates into compact monomers. Higher concentrations of urea (7–8 M) promote complete denaturation of the enzyme. We report here that the H176N mutation in this enzyme, found in hum...
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| Autori principali: | , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Wiley-Blackwell
2007
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2206963/ https://ncbi.nlm.nih.gov/pubmed/17660255 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1110/ps.072921507 |
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