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Study of Two Tyrosine Kinase Inhibitors on Growth and Signal Transduction in Polycythemia Vera
OBJECTIVE: An activating somatic mutation of Janus kinase 2 V617F (JAK2(V617F)) is present in most polycythemia vera (PV) patients. We studied efficacy of 2 potent tyrosine kinase inhibitors (TKI), AEE788 and AMN107 in vitro on cells bearing this mutation. PATIENTS AND METHODS: We employed reporter...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2007
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2206678/ https://ncbi.nlm.nih.gov/pubmed/17976517 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.exphem.2007.08.018 |
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