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Structure of the Q67H mutant of R67 dihydrofolate reductase-NADP(+) complex reveals a novel cofactor binding mode
Plasmid-encoded bacterial R67 dihydrofolate reductase (DHFR) is a NADPH-dependent enzyme unrelated to chromosomal DHFR in amino acid sequence and structure. R67 DHFR is insensitive to the bacterial drug trimethoprim in contrast to chromosomal DHFR. The crystal structure of Q67H mutant of R67 DHFR bo...
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| 主要な著者: | , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Cold Spring Harbor Laboratory Press
2007
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2206676/ https://ncbi.nlm.nih.gov/pubmed/17473013 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1110/ps.062740907 |
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