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Structure of the Q67H mutant of R67 dihydrofolate reductase-NADP(+) complex reveals a novel cofactor binding mode

Plasmid-encoded bacterial R67 dihydrofolate reductase (DHFR) is a NADPH-dependent enzyme unrelated to chromosomal DHFR in amino acid sequence and structure. R67 DHFR is insensitive to the bacterial drug trimethoprim in contrast to chromosomal DHFR. The crystal structure of Q67H mutant of R67 DHFR bo...

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Bibliografische gegevens
Hoofdauteurs: Divya, N., Grifith, E., Narayana, Narendra
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Cold Spring Harbor Laboratory Press 2007
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2206676/
https://ncbi.nlm.nih.gov/pubmed/17473013
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1110/ps.062740907
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