Structure of NADP(+)-bound 7β-hydroxysteroid dehydrogenase reveals two cofactor-binding modes

In mammals, bile acids/salts and their glycine and taurine conjugates are effectively recycled through enterohepatic circulation. 7β-Hydroxysteroid dehydrogenases (7β-HSDHs; EC 1.1.1.201), including that from the intestinal microbe Collinsella aerofaciens, catalyse the NADPH-dependent reversible oxi...

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Foilsithe in:Acta Crystallogr F Struct Biol Commun
Main Authors: Wang, Rui, Wu, Jiaquan, Jin, David Kin, Chen, Yali, Lv, Zhijia, Chen, Qian, Miao, Qiwei, Huo, Xiaoyu, Wang, Feng
Formáid: Artigo
Teanga:Inglês
Foilsithe: International Union of Crystallography 2017
Ábhair:
Research Communications
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5417313/
https://ncbi.nlm.nih.gov/pubmed/28471355
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S2053230X17004460
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