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Two distinct mechanisms of silencing by the KvDMR1 imprinting control region

Imprinting control regions (ICRs) are known to repress genes by utilizing one of two mechanisms, CTCF-mediated insulation or the transcription of non-coding RNAs (ncRNAs). The KvDMR1 ICR contains both the promoter for the Kcnq1ot1 ncRNA and two CTCF-binding sites located within sequences exhibiting...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Shin, Jong-Yeon, Fitzpatrick, Galina V, Higgins, Michael J
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Nature Publishing Group 2008
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC2206141/
https://ncbi.nlm.nih.gov/pubmed/18079696
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601960
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