Silencing of CDKN1C (p57(KIP2)) is associated with hypomethylation at KvDMR1 in Beckwith–Wiedemann syndrome

Context: Beckwith–Wiedemann syndrome (BWS) arises by several genetic and epigenetic mechanisms affecting the balance of imprinted gene expression in chromosome 11p15.5. The most frequent alteration associated with BWS is the absence of methylation at the maternal allele of KvDMR1, an intronic CpG is...

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Hlavní autoři: Diaz-Meyer, N, Day, C, Khatod, K, Maher, E, Cooper, W, Reik, W, Junien, C, Graham, G, Algar, E, Der Kaloustian, V M, Higgins, M
Médium: Artigo
Jazyk:Inglês
Vydáno: BMJ Group 2003
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Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1735305/
https://ncbi.nlm.nih.gov/pubmed/14627666
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/jmg.40.11.797
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