Guanosine triphosphatase stimulation of oncogenic Ras mutants

Interest in the guanosine triphosphatase (GTPase) reaction of Ras as a molecular drug target stems from the observation that, in a large number of human tumors, Ras is characteristically mutated at codons 12 or 61, more rarely 13. Impaired GTPase activity, even in the presence of GTPase activating p...

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Bibliografiska uppgifter
Huvudupphovsmän: Ahmadian, Mohammad Reza, Zor, Tsaffrir, Vogt, Dorothee, Kabsch, Wolfgang, Selinger, Zvi, Wittinghofer, Alfred, Scheffzek, Klaus
Materialtyp: Artigo
Språk:Inglês
Publicerad: The National Academy of Sciences 1999
Ämnen:
Biological Sciences
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC22057/
https://ncbi.nlm.nih.gov/pubmed/10359839
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