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A cross-strand Trp–Trp pair stabilizes the hPin1 WW domain at the expense of function

Using the human Pin1 WW domain (hPin1 WW), we show that replacement of two nearest neighbor non-hydrogen-bonded residues on adjacent β-strands with tryptophan (Trp) residues increases β-sheet thermodynamic stability by 4.8 kJ mol(−1) at physiological temperature. One-dimensional NMR studies confirme...

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Autori principali: Jäger, Marcus, Dendle, Maria, Fuller, Amelia A., Kelly, Jeffery W.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Cold Spring Harbor Laboratory Press 2007
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2204138/
https://ncbi.nlm.nih.gov/pubmed/17766376
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1110/ps.072904107
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