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mRNA cap recognition: Dominant role of enhanced stacking interactions between methylated bases and protein aromatic side chains

We have determined, by high resolution x-ray analysis, 10 structures comprising the mRNA cap-specific methyltransferase VP39 or specific mutants thereof in the presence of methylated nucleobase analogs (N1-methyladenine, N3-methyladenine, N1-methylcytosine, N3-methylcytosine) and their unmethylated...

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Hlavní autoři: Hu, Guanghui, Gershon, Paul D., Hodel, Alec E., Quiocho, Florante A.
Médium: Artigo
Jazyk:Inglês
Vydáno: The National Academy of Sciences 1999
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC22034/
https://ncbi.nlm.nih.gov/pubmed/10377383
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