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mRNA cap recognition: Dominant role of enhanced stacking interactions between methylated bases and protein aromatic side chains

We have determined, by high resolution x-ray analysis, 10 structures comprising the mRNA cap-specific methyltransferase VP39 or specific mutants thereof in the presence of methylated nucleobase analogs (N1-methyladenine, N3-methyladenine, N1-methylcytosine, N3-methylcytosine) and their unmethylated...

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Detalhes bibliográficos
Main Authors: Hu, Guanghui, Gershon, Paul D., Hodel, Alec E., Quiocho, Florante A.
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences 1999
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC22034/
https://ncbi.nlm.nih.gov/pubmed/10377383
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