Mutations that mimic phosphorylation of the HIV-1 matrix protein do not perturb the myristyl switch

Recent studies indicate that the matrix domain (MA) of the HIV-1 Gag polyprotein directs Gag to the plasma membrane for virus assembly via a phosphatidylinositol-4,5-bisphosphate (PIP(2))–dependent myristyl switch mechanism. MA also has been reported to direct nuclear trafficking via nuclear import...

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Bibliographic Details
Main Authors: Saad, Jamil S., Kim, Andrew, Ghanam, Ruba H., Dalton, Amanda K., Vogt, Volker M., Wu, Zhibin, Lu, Wuyuan, Summers, Michael F.
Format: Artigo
Language:Inglês
Published: Cold Spring Harbor Laboratory Press 2007
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2203364/
https://ncbi.nlm.nih.gov/pubmed/17656588
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1110/ps.072987607
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