The effect of ABCG2 V12M, Q141K and Q126X, known functional variants in vitro, on the disposition of lamivudine

AIMS: To evaluate the effects of three ABCG2 variants (Q141K, V12M and Q126X), which are known to have altered transport properties in vitro, on the disposition of lamivudine in healthy subjects. METHODS: To evaluate whether lamivudine is a substrate of ABCG2, intracellular accumulation and vectoria...

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Bibliografiske detaljer
Main Authors: Kim, Ho-Sook, Sunwoo, Yu Eun, Ryu, Ji Young, Kang, Ho-Jin, Jung, Hye-Eun, Song, Im-Sook, Kim, Eun-Young, Shim, Joo-Cheol, Shon, Ji-Hong, Shin, Jae-Gook
Format: Artigo
Sprog:Inglês
Udgivet: Blackwell Science Inc 2007
Fag:
Pharmacogenetics
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2203270/
https://ncbi.nlm.nih.gov/pubmed/17509035
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2007.02944.x
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