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Effect of rifampin on enantioselective disposition and anti‐hypertensive effect of benidipine

AIMS: In vitro study showed that benidipine is exclusively metabolized by cytochrome P450 (CYP) 3A. This study evaluated the effect of rifampin on the enantioselective disposition and anti‐hypertensive effect of benidipine. METHODS: Benidipine (8 mg) was administered to healthy subjects with or with...

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Detalhes bibliográficos
Publicado no:Br J Clin Pharmacol
Main Authors: Sunwoo, Yu Eun, Nguyen, Phuong Thi Thu, Chien, Chin May, Ryu, Ji Young, Shon, Jihong, Shin, Jae‐Gook
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6422640/
https://ncbi.nlm.nih.gov/pubmed/30589098
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.13848
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