Phage-display library selection of high-affinity human single-chain antibodies to tumor-associated carbohydrate antigens sialyl Lewis(x) and Lewis(x)

mAbs against tumor-associated carbohydrate antigens have the potential to play a prominent role in cancer immunotherapy. However, it has not been possible to fully exploit the clinical utility of such antibodies primarily, because those of adequate affinity could be derived only from murine sources....

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Veröffentlicht in:	Proc Natl Acad Sci U S A
Hauptverfasser:	Mao, Shenlan, Gao, Changshou, Lo, Chih-Hung L., Wirsching, Peter, Wong, Chi-Huey, Janda, Kim D.
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	National Academy of Sciences 1999
Schlagworte:	Biological Sciences
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC22023/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10359820/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.96.12.6953
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