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Role of epigenetic modifications in normal globin gene regulation and butyrate-mediated induction of fetal hemoglobin
Butyrate is a prototype of histone deacetylase inhibitors that is believed to reactivate silent genes by inducing epigenetic modifications. Although butyrate was shown to induce fetal hemoglobin (HbF) production in patients with hemoglobin disorders, the mechanism of this induction has not been full...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Society of Hematology
2007
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2200921/ https://ncbi.nlm.nih.gov/pubmed/17638855 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2007-02-076091 |
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