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Role of epigenetic modifications in normal globin gene regulation and butyrate-mediated induction of fetal hemoglobin

Butyrate is a prototype of histone deacetylase inhibitors that is believed to reactivate silent genes by inducing epigenetic modifications. Although butyrate was shown to induce fetal hemoglobin (HbF) production in patients with hemoglobin disorders, the mechanism of this induction has not been full...

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Detalhes bibliográficos
Main Authors: Fathallah, Hassana, Weinberg, Rona S., Galperin, Yelena, Sutton, Millicent, Atweh, George F.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2007
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2200921/
https://ncbi.nlm.nih.gov/pubmed/17638855
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2007-02-076091
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