Thrombospondin-1 stimulates platelet aggregation by blocking the antithrombotic activity of nitric oxide/cGMP signaling

Platelet α-granules constitute the major rapidly releasable reservoir of thrombospondin-1 in higher animals. Although some fragments and peptides derived from thrombospondin-1 stimulate or inhibit platelet aggregation, its physiologic function in platelets has remained elusive. We now show that endo...

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Hauptverfasser: Isenberg, Jeff S., Romeo, Martin J., Yu, Christine, Yu, Christine K., Nghiem, Khauh, Monsale, Jude, Rick, Margaret E., Wink, David A., Frazier, William A., Roberts, David D.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Hematology 2008
Schlagworte:
Hemostasis, Thrombosis, and Vascular Biology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2200855/
https://ncbi.nlm.nih.gov/pubmed/17890448
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2007-06-098392
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