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Thrombospondin-1 Inhibition of Vascular Smooth Muscle Cell Responses Occurs via Modulation of Both cAMP and cGMP

Nitric oxide (NO) drives pro-survival responses in vascular cells and limits platelet adhesion, enhancing blood flow and minimizing thrombosis. The matricellular protein thrombospondin-1 (TSP1), through interaction with its receptor CD47, inhibits soluble guanylyl cyclase (sGC) activation by NO in v...

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Bibliografische gegevens
Hoofdauteurs: Yao, Mingyi, Roberts, David D., Isenberg, Jeff S.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2010
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3026097/
https://ncbi.nlm.nih.gov/pubmed/20971192
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.phrs.2010.10.014
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