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Activator-specific requirement of properdin in the initiation and amplification of the alternative pathway complement
Properdin is a positive regulator of alternative pathway (AP) complement. The current understanding of properdin function is that it facilitates AP complement activation by stabilizing the C3 convertase C3bBb. Properdin-deficient patients are susceptible to lethal meningococcal infection, but the me...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Society of Hematology
2008
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2200840/ https://ncbi.nlm.nih.gov/pubmed/17916747 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2007-05-089821 |
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