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Genetic and therapeutic targeting of properdin in mice prevents complement-mediated tissue injury

The alternative pathway (AP) of complement activation is constitutively active and must be regulated by host proteins to prevent autologous tissue injury. Dysfunction of AP regulatory proteins has been linked to several human inflammatory disorders. Properdin is a positive regulator of AP complement...

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Autors principals: Kimura, Yuko, Zhou, Lin, Miwa, Takashi, Song, Wen-Chao
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2010
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2947218/
https://ncbi.nlm.nih.gov/pubmed/20941861
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI41782
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