Genetic and therapeutic targeting of properdin in mice prevents complement-mediated tissue injury

The alternative pathway (AP) of complement activation is constitutively active and must be regulated by host proteins to prevent autologous tissue injury. Dysfunction of AP regulatory proteins has been linked to several human inflammatory disorders. Properdin is a positive regulator of AP complement...

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Bibliographic Details
Main Authors: Kimura, Yuko, Zhou, Lin, Miwa, Takashi, Song, Wen-Chao
Format: Artigo
Language:Inglês
Published: American Society for Clinical Investigation 2010
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2947218/
https://ncbi.nlm.nih.gov/pubmed/20941861
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI41782
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