A Stat5b transgene is capable of inducing CD8(+) lymphoblastic lymphoma in the absence of normal TCR/MHC signaling

Stat5 proteins are critical signaling molecules activated by many cytokines. Within the immune system, Stat5 plays important roles related to the development of thymocytes and proliferation of T cells. Stat5 has been implicated in malignant transformation, and moreover, the activated tyrosine phosph...

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Main Authors: Bessette, Katherine, Lang, Mark L., Fava, Roy A., Grundy, Martin, Heinen, Jennifer, Horne, Laurie, Spolski, Rosanne, Al-Shami, Amin, Morse, Herbert C., Leonard, Warren J., Kelly, John A.
Format: Artigo
Jezik:Inglês
Izdano: American Society of Hematology 2008
Teme:
Neoplasia
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2200817/
https://ncbi.nlm.nih.gov/pubmed/17890450
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2007-04-084707
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