Cbfa1-independent decrease in osteoblast proliferation, osteopenia, and persistent embryonic eye vascularization in mice deficient in Lrp5, a Wnt coreceptor

The low-density lipoprotein receptor–related protein (Lrp)-5 functions as a Wnt coreceptor. Here we show that mice with a targeted disruption of Lrp5 develop a low bone mass phenotype. In vivo and in vitro analyses indicate that this phenotype becomes evident postnatally, and demonstrate that it is...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Autori principali: Kato, Masaki, Patel, Millan S., Levasseur, Regis, Lobov, Ivan, Chang, Benny H.-J., Glass, Donald A., Hartmann, Christine, Li, Lan, Hwang, Tae-Ho, Brayton, Cory F., Lang, Richard A., Karsenty, Gerard, Chan, Lawrence
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Rockefeller University Press 2002
Soggetti:
Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2199263/
https://ncbi.nlm.nih.gov/pubmed/11956231
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200201089
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi