Ku70 Is Required for DNA Repair but Not for T Cell Antigen Receptor Gene Recombination In Vivo

Ku is a complex of two proteins, Ku70 and Ku80, and functions as a heterodimer to bind DNA double-strand breaks (DSB) and activate DNA-dependent protein kinase. The role of the Ku70 subunit in DNA DSB repair, hypersensitivity to ionizing radiation, and V(D)J recombination was examined in mice that l...

Full beskrivning

Sparad:
Bibliografiska uppgifter
Huvudupphovsmän: Ouyang, Honghai, Nussenzweig, Andre, Kurimasa, Akihiro, Soares, Vera da Costa, Li, Xiaoling, Cordon-Cardo, Carlos, Li, Wen-hui, Cheong, Nge, Nussenzweig, Michel, Iliakis, George, Chen, David J., Li, Gloria C.
Materialtyp: Artigo
Språk:Inglês
Publicerad: The Rockefeller University Press 1997
Ämnen:
Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2199057/
https://ncbi.nlm.nih.gov/pubmed/9294146
Taggar: Lägg till en tagg
Inga taggar, Lägg till första taggen!

Liknande verk