Catalytic subunit of DNA-dependent protein kinase: Impact on lymphocyte development and tumorigenesis

The DNA-dependent protein kinase (DNA-PK) consists of a heterodimer DNA-binding complex, Ku70 and Ku80, and a large catalytic subunit, DNA-PKcs. To examine the role of DNA-PKcs in lymphocyte development, radiation sensitivity, and tumorigenesis, we disrupted the mouse DNA-PKcs by homologous recombin...

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Detalhes bibliográficos
Main Authors: Kurimasa, Akihiro, Ouyang, Honghai, Dong, Li-jin, Wang, Sa, Li, Xiaoling, Cordon-Cardo, Carlos, Chen, David J., Li, Gloria C.
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences 1999
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC15475/
https://ncbi.nlm.nih.gov/pubmed/9990036
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