Catalytic subunit of DNA-dependent protein kinase: Impact on lymphocyte development and tumorigenesis

The DNA-dependent protein kinase (DNA-PK) consists of a heterodimer DNA-binding complex, Ku70 and Ku80, and a large catalytic subunit, DNA-PKcs. To examine the role of DNA-PKcs in lymphocyte development, radiation sensitivity, and tumorigenesis, we disrupted the mouse DNA-PKcs by homologous recombin...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Kurimasa, Akihiro, Ouyang, Honghai, Dong, Li-jin, Wang, Sa, Li, Xiaoling, Cordon-Cardo, Carlos, Chen, David J., Li, Gloria C.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1999
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC15475/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9990036/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.96.4.1403
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